chrom logd (Chrom Tech)

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Chrom Tech chrom logd
Chrom Logd, supplied by Chrom Tech, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/chrom+logd/chrom+logd/pm41483507-542-14-14
Average 86 stars, based on 1 article reviews

chrom logd - by Bioz Stars, 2026-10

86/100 stars

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Binding Assay:

Article Title: Chemical modification of STL427944 toward morpholine-based 1,3,5-triazines as anticancer agents targeting FOXM1: green synthesis, biological evaluation and ADME-Tox profiling in a colorectal cancer model.
Article Snippet: Morpholine-based 1,3,5-triazines are a promising chemotype for anticancer drug discovery, particularly through inhibition of transcription factor FOXM1, a key driver of colorectal cancer (CRC) progression.. In this study, we developed an ultrasound-assisted, eco-friendly synthesis of 17 new derivatives and evaluated their activity in CRC models.. Compared with conventional conditions, the sonochemical protocol offered significantly shorter reaction times, more sustainable solvent use, and improved compliance with Green Chemistry Principles.

Selection:

Article Title: Novel antitubercular agents based on 2,4-disubstituted 5-(aryl-2-ylmethyl)-5H-pyrrolo[3,2-d]pyrimidines.
Article Snippet: .. 1 [42]: Chrom logD = 0.0525 × CHI -1.467 (1) In addition, the Property Forecast Index (PFI), the sum of the number of aromatic rings(#Ar) and a lipophilicity measure, is used to reflect the principle of simultaneous minimisation of lipophilicity and aromaticity, which supports the selection of oral clinical candidates in GKS [16,25]. ..

Article Title: Green and Efficient Synthetic Protocol for 1,3,5-Triazine Derivatives with Anticancer Potential Against Colorectal Cancer.
Article Snippet: .. Experimentally determined CHI values were converted to chrom logD using the following equation [53]: Chrom logD = 0.0525 × CHI − 1.467 (1) In addition, the Property Forecast Index (PFI), the sum of the number of aromatic rings(#Ar), and a lipophilicity measure are used to reflect the principle of simultaneous minimization of lipophilicity and aromaticity [46], which supports the selection of oral clinical candidates in GKS [47]. ..

Article Title: Novel tacrine-based multi-target directed Ligands: Enhancing cholinesterase inhibition, NMDA receptor antagonism, and CNS bioavailability for Alzheimer's disease treatment.
Article Snippet: .. Experimentally determined CHI values have been converted to chrom logD using the following equation [93]: Chrom log D=0.0525 × CHI – 1.467 (1) In addition, the Property Forecast Index (PFI), the sum of the number of aromatic rings(#Ar), and a lipophilicity measure are used to reflect the principle of simultaneous minimisation of lipophilicity and aromaticity [94], which supports the selection of oral clinical candidates in GKS [95]. .. PFI=Chrom log D (7.4)+#Ar (2) In case of tha HSA, the obtained result can be converted to a more informative percent of binding to (%HSA) using the following equations [89].

Residue:

Article Title: Identification of a p21-activated kinase 1 (PAK1) inhibitor with 10-fold selectivity against PAK2.
Article Snippet: Deidre M. Johns, Jason Olejniczak, Anjali Babbar, Christopher D. Boone, Ozgur Cakici, Melinda Cheng, Qing-Qing Cheng, Alex Dementiev, Mariam Eick, Nicky Ferdyan, Eric Fontano, Aaron Forman, Ryan Kozlowski, Szu-Wei Lee, Shital Mehta, Kayla Mowery, Brion Murray, Vivian Nguyen, Andrea Olland, Kim Phan, Lily Rivera, Mark Sabat, Paul Sprengeler, Karthik Srinivasan, Zhi Sun, Robert K. Suto, Ty Wilkinson, Chao Wang, Ning Yu, Meirong Xu, Vikas Goel, Gavin Hirst, Siegfried Reich

Transformation Assay:

Article Title: Comparative Study of Click Handle Stability in Common Ligation Conditions
Article Snippet: .. CHI is linearly transformed into Chrom LogD by least-square fitting of experimental CHI values to calculated ClogP values for over 20 k research compounds using the following formula: Chrom LogD = 0.0857CHI-2.00. .. The average error of the assay is ±3 CHI unit or ±0.25 Chrom LogD.

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